Sentence examples for multiple pathway interactions from inspiring English sources

Major challenges also hindering the routine application of NGS include bioinformatic interpretation of enormous quantities of data, incomplete functional understanding of multiple pathway interactions or uncommon mutations, and the need to validate sequenced mutations (Braggio et al, 2013).

However, beyond radicals, metal ions can disrupt normal cell and tissue function through multiple pathways including interactions with proteins and other biomolecules and disruption of membrane potentials [4].

Antagonism of VEGF, therefore, may have multiple pathways of interaction with other therapies, as well as direct antitumour effects.

The current approach is limited to address the complexity of in vivo cancer angiogenesis which not only involves multiple cell type and signalling pathway interactions, but the interactions are also geometrically and temporally restricted.

Suppression of genes within the RB and p53 pathways illustrates the capacity to use siRNA to dissect functional interactions among multiple pathway members.

Proteins involved in multiple pathways have more interactions with other proteins and tend to be functionally essential [ 58, 59].

Taken together, in addition to lowering IOP, BMD may prevent glaucomatous retinal degeneration by stimulating multiple pathways including glia neuron interactions.

These results suggest that, in addition to lowering IOP, BMD prevents glaucomatous retinal degeneration by stimulating multiple pathways including glia neuron interactions.

Furthermore, integration of the pathway in local varieties will also entail pyramiding of multiple traits, yet little is known about pathway interactions and competition for common substrates.

The high overlap of protein interactions in the paths between pathways indicates the presence of proteins that are involved in multiple paths and might act as key regulators of pathway interactions.

However, etiology of complex diseases involves multiple pathways and their dynamic interactions with environmental factors (Sing et al., 2003; Zerba et al., 1996).