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In addition, a stable and conjugative plasmid pSEVA341 with a high-copy number was constructed to contain a LacIq-Ptrc system for the inducible expression of multiple pathway genes.
These tools must be able to simultaneously evaluate the effectiveness of individual mutant proteins while balancing the expression of transporters and multiple pathway genes.
To determine which WRKY TFs were possible regulators of TIA production, we sought to measure the expression of multiple pathway genes such as G10H, TDC, and STR.
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When we characterized the function of the 34 prostate genes, we found they were significantly associated with BCR free survival (Figure 6) and to multiple cancer pathway genes (Figure 7).
Further, somatic mutations were identified in multiple Notch pathway genes, including those that encode Nicastrin, MAML1 and Notch2, in samples from CMML patients, demonstrating a tumor-suppressive role for Notch signaling in addition to involvement in early HSC differentiation (Klinakis et al., 2011).
To test whether genetic variations in the multiple complement pathway genes impact macular degeneration risk, Dinu et al. analyzed the existing genome-wide association study data of Klein et al. [45], restricting the analyses to genes in the complement pathway in subjects carrying the CFH risk allele.
Remarkably the combined analysis of MYC, HER2, CCND1 and PTEN aberrations suggested that aberrations of multiple PTEN/AKT pathway genes have a strong additive effect on breast cancer prognosis.
This finding underscores the need to develop animal models of dopamine signaling that accurately reflect the effects of reduced expression of multiple neurotransmitter signaling pathway genes, rather than complete loss of function of a single gene.
In addition, multiple pathways and gene homologs are often present, thus further increasing Rhodococcus catabolic versatility and efficiency.
Our data show that multiple pathways and gene sets related to energy homeostasis are changed in peripheral tissues at the onset of lactation.
Multiple pathways and gene sets related to energy homeostasis are changed in mammary, liver and adipose tissues during the transition from pregnancy to lactation.
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