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Knowledge of the connections may suggest alternative targets that would have multiple pathway effects.
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Given that many 2OG-dependent dioxygenases have been implicated in the regulation of multiple pathways, global effects on gene expression and metabolism are not surprising when their enzymatic functions get perturbed or ablated.
Resulting effects rely again on the multiple pathway hit strategy built into MB.
Previous research has identified multiple pathways through which neighborhood effects operate to influence health outcomes.
The panoply of potential mechanisms defending body weight helps explain why the field is moving toward targeting multiple pathways by harnessing additive effects of current drugs, which individually produce ∼5% weight loss (45).
Further studies demonstrated that multiple pathways mediated the preventive effect of AST.
Finally, activation of Akt and effects on insulin secretion and signaling by FXR suggest that multiple pathways may be mediating its effects on glucose metabolism.
After all, these problems are characterized by multiple sources, multiple agents, multiple pathways, multiple exposure routes, multiple health effects, long delay periods between cause and effect, cross-bordering scale effects, etc.
They mediate their immunosuppressive effects by multiple pathways [ 198].
These results underscore the ability of EPO to counter injury effects on multiple pathways.
Thus, restoration of RFC pathway function may provide beneficial effects on multiple pathways of increasing interest in controlling cancer cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com