4 Aside from multiple pathophysiological defects, other factors that impede efforts to attain glycemic goals include adverse effects of the currently available agents for T2DM.
Therefore, there is significant merit in the use of combination therapies to target these multiple pathophysiological defects.
Intermedin (IMD), also called adrenomedullin 2 (ADM-2), is a novel member of the calcitonin gene-related peptide (CGRP) superfamily [ 13, 14] and has been shown to have pathophysiological effects in multiple disease processes involving the circulatory and renal systems [ 15, 16, 23, 24].
and of effects on multiple pathophysiological aspects of type 2 diabetes [ 9].
These correlations indicate that the SHQ can evaluate the effects of multiple pathophysiological processes in sarcoidosis that involve several organ systems.
Initial data suggest that the clinical benefits observed in RELAX-AHF may be explained by the effect of serelaxin on the multiple pathophysiological processes that drive the short- and long-term consequences of AHF.
BN.GK-Nidd/gk1 congenics, as CSS, are powerful tools for profiling the phenotypic effects of a large number of gene variants, which collectively are involved either directly or indirectly in multiple pathophysiological endpoints.
In the literature, multiple pathophysiological mechanisms are described to explain this association, and are here discussed.
This might be a sign of a deeper comprehension of the detrimental pathophysiological effects of IAH.
In addition, it was reported to play important roles in multiple pathophysiological processes including development, aging, and degeneration.
