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Patients with type 2 diabetes exhibit multiple pathophysiological deficits, including declining ß-cell function and a failure to suppress postprandial glucagon secretion [ 2].
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Therefore, there is significant merit in the use of combination therapies to target these multiple pathophysiological defects.
14 It is clear that what was needed were agents or greater use of combinations of agents that directly target the multiple pathophysiological defects in T2DM.
4 Aside from multiple pathophysiological defects, other factors that impede efforts to attain glycemic goals include adverse effects of the currently available agents for T2DM.
In the literature, multiple pathophysiological mechanisms are described to explain this association, and are here discussed.
In addition, it was reported to play important roles in multiple pathophysiological processes including development, aging, and degeneration.
Multiple pathophysiological pathways are involved in the relationship between depressive symptoms and atherosclerosis and its clinical manifestations and progression.
Multiple pathophysiological changes characterize the early post-traumatic phase.
β-Catenin participates in multiple pathophysiological processes, including embryogenesis, tissue homeostasis, and tumor development [ 145].
The mechanism(s) by which 2ME2 exerts its preclinical antiarthritic activity likely involves multiple pathophysiological processes.
and of effects on multiple pathophysiological aspects of type 2 diabetes [ 9].
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CEO of Professional Science Editing for Scientists @ prosciediting.com