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In some lines, multiple pathology phenotypes were observed, consistent with multiple clinical phenotype hits.
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Score range 1-5; lower scores indicate less severe multiple pathology.
This further highlights the need for quantitative data in studies aiming to identify subtle and novel clinico-pathological phenotypes which may be characterized by the simultaneous presence of multiple pathologies.
Down-regulated VEGF-A165b expression correlates with cellular switching to a pro-angiogenic phenotype that is associated with multiple pathologies including diabetic retinopathy and several adult epithelial cancers [ 18, 19].
However, a deficiency of different clock components has different effects on longevity: BMAL1 deficiency results in a significantly reduced lifespan and multiple pathologies [ 9], a deficiency of CLOCK results in a milder phenotype, whereas the effects on longevity as a result of a deficiency of PERIODs [ 24] and a mutation of Clock [ 16] can be revealed only after challenge with irradiation.
He said: "What we have found is that many preventable deaths are occurring in elderly people with multiple pathologies.
Consequently, multiple pathologies resulting in multiple symptoms are common phenomena in the elderly.
These have been employed with increasing frequency for the management of multiple pathologies [5].
"Dr. Albright is intimately familiar with the ways of Washington and its multiple pathologies," Aftergood says.
Disrupted redox balance is implicated in multiple pathologies including malignant progression and tumor angiogenesis.
Another specimen cataloged as TMP94.12.602 bears multiple pathologies.
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