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Disrupted redox balance is implicated in multiple pathologies including malignant progression and tumor angiogenesis.
The role of TCS has evolved as an imaging modality for the brain parenchyma in the setting of multiple pathologies, including movement disorders, parkinsonism and follow up of vasospasm post SAH using transcranial Doppler [5].
However, when the balance between ROS production overrides the antioxidant capability of the cells, it leads to oxidative stress which is highly damaging to cellular macromolecules (i.e. DNA, lipids and proteins), and is linked to multiple pathologies including neurodegenerative diseases, diabetes, cancer and premature aging [44, 95].
Furin function is important for normal cells and also in multiple pathologies including malignancy and anthrax.
It is thus a characteristic of multiple pathologies including cancer, cardiovascular disease, arthritis, psoriasis, macular degeneration, and diabetic retinopathy.
ERS mutations are associated with multiple pathologies including myopathy, respiratory failure and retinitis pigmentosa [ 52].
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Indeed, mutations of chromatin effector domains found within several proteins are associated with multiple human pathologies, including cancer and immunodeficiency syndromes.
Activation of the mTOR signalling pathway contributes to multiple human pathologies including cancer and tissue hypertrophy.
Wolcott-Rallison syndrome has been associated with multiple other pathologies including osteopenia, hepatic and renal complications, cardiovascular disease and mental retardation.
Consequently, since their discovery just over 20 years ago, miRNAs have been identified as key regulators of complex biological processes linked to multiple cardiovascular pathologies, including left ventricular hypertrophy, ischaemic heart disease, heart failure, hypertension and arrhythmias.
Another major difficulty is the fact that this aged population is frequently affected by multiple coexisting pathologies, including osteoarthritis and other seronegative arthritides, which can potentially mask a beneficial therapeutic effect.
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