Accumulating evidence shows that autophagy stimulation and ROS accumulation are linked to multiple pathological processes, including cancer, neurodegenerative diseases, type-II diabetes, immune diseases and aging [ 14, 40].
Thus, the discovery of upstream pathways in different cells types that contribute to multiple pathological cardiometabolic processes in T2D may lead to a unique class of T2D therapies that have increased efficacy and safety than those that are currently available.
In a research setting, knowledge of the type and location of multiple pathological mutations in a specific disease gene might reveal valuable indications towards functionally critical protein domains and/or motifs and disease mechanisms.
Atherosclerosis is a chronic disease of the vascular wall involving multiple pathological processes, such as lipid retention and inflammations in many different types of cells such as various inflammatory cells, endothelial cells, and VSMCs [ 57].
Multiple pathological derangements contribute to the chronic hyperglycemia and hypertriglyceridemia that characterize type 2 diabetes mellitus (T2DM) [ 1– 3].
Dysregulation of cell metabolism occurs under multiple pathological conditions.
Our study suggests that TGFβ contributes to multiple pathological processes responsible for oral mucositis development.
Oral mucositis has multiple pathological processes, hence targeting one of them is insufficient for therapeutic efficacy.
BRD4, a bromodomain and extraterminal domain (BET) family member, is an attractive target in multiple pathological settings, particularly cancer.
Clinical information on pathological types was collected through pathological reports.
