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See the Guidelines for Authors for a complete description of levels of evidence Soft tissue sarcomas, a heterogeneous group of malignancies, are challenging to diagnose and treat because of their rarity, various clinical presentations, disease course, and multiple pathological subtypes.
This great effort in biomedical research has lead to a large need for tools and strategies that allow clinicians to translate the genome-wide expression data into useful information, such as transparent and robust signatures to characterize and distinguish multiple pathological subtypes [ 2].
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Renal tumors can manifest as multiple types of renal cell carcinoma, but certain pathological subtypes (including chromophobe, oncocytoma, and oncocytic hybrid tumors) are more commonly seen.
Despite the large increase of transcriptomic studies that look for gene signatures on diseases, there is still a need for integrative approaches that obtain separation of multiple pathological states providing robust selection of gene markers for each disease subtype and information about the possible links or relations between those genes.
Dysregulation of cell metabolism occurs under multiple pathological conditions.
Furthermore, the ADC shows potential for assessing pathological subtypes and for tumour grade differentiation [14, 60, 88, 89, 90, 91, 92].
Our study suggests that TGFβ contributes to multiple pathological processes responsible for oral mucositis development.
The remaining trials accepted all pathological subtypes.
The main pathological subtypes include adenocarcinoma and squamous cell carcinoma.
Multiple pathological pathways contribute to the final phenotype of PE.
The pathological subtypes did not affect 5-year disease-free survival significantly (P=0.9).
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