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Our study suggests that TGFβ contributes to multiple pathological processes responsible for oral mucositis development.
Oral mucositis has multiple pathological processes, hence targeting one of them is insufficient for therapeutic efficacy.
Our studies show that the preventive and therapeutic effects of Smad7 are due to blocking multiple pathological processes of oral mucositis as discussed below.
Therefore, in response to the molecular complexity of this disease, a new strategy has recently emerged aimed at simultaneously targeting multiple pathological processes involved in the pathogenesis cascade.
The major objective of this review is to evaluate the known functions of Smad7, with a particular focus on its molecular mechanisms and its function in blocking multiple pathological processes in oral mucositis.
At the pathological level, Smad7 targets multiple pathological processes required for oral mucositis development, particularly through its effects on proliferation, apoptosis, migration in keratinocytes, and reducing inflammation in the stroma.
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Thus, the discovery of upstream pathways in different cells types that contribute to multiple pathological cardiometabolic processes in T2D may lead to a unique class of T2D therapies that have increased efficacy and safety than those that are currently available.
In short, low FT3 levels might represent an integrative measure of multiple harmful pathological processes occurring simultaneously in patients with critical illness, such as inflammation status and cardiac dysfunction, which are associated with adverse outcomes [ 24, 40].
Nitric oxide (NO) mediates multiple physiological and pathological processes in the etiology of cancer [1].
Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play important roles in multiple physiological and pathological processes.
The Nme gene family is involved in multiple physiological and pathological processes such as cellular differentiation, development, metastatic dissemination, and cilia functions.
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multiple pathogenic processes
multiple disease processes
multiple pathological aspects
multiple pathological characteristics
multiple degenerative processes
multiple cellular processes
multiple pathological lesions
multiple pathological events
multiple pathological conditions
multiple developmental processes
multiple pathological derangements
multiple pathological effects
multiple pathological causes
multiple pathological routes
multiple cytoplasmic processes
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