Adjuvant CCT has been performed on patients with multiple pathological risk factors (at least 3) since 2008.
Adjuvant CCT has been performed on patients with postoperative KPS scores >70 and multiple pathological risk factors (at least 3) since 2008.
Thus, we show that directed evolution could be used to develop next-generation therapeutics against multiple redundant pathological factors.
HYPOTHESIS: Analysis of multiple clinical and pathological factors in patients undergoing therapeutic hyperthermic isolated limb perfusion for extremity melanoma can identify variables with prognostic significance.
Multiple and often intertwined pathological factors, including atrophy, neurodegeneration, inflammation, stroke and genetic-related factors, cause dementia [ 1].
Intestinal barrier dysfunction is one of the major contributing factors in multiple pathological conditions of the gastrointestinal tract.
Mono-target therapy often fails to treat chronic diseases that are often induced by multiple pathogenic factors and often involve multiple pathological changes, it is necessary to expand drug discovery toward multi-target approach.
We hypothesize that CP occurs as a result of multiple pathological mechanisms (pathways) that are initiated by different metabolic or environmental factors (etiologies) and may be influenced differentially by downstream genetic risk factors.
For each the exclusively deleted and amplified cytobands, we analysed the relationships between CNAs and the main pathological factors : size of the largest tumor, tumor number (single vs multiple), macrovascular invasion, histological vascular invasion and intraneural invasion, pathological stage and primary chemotherapy.
Brain-derived neurotrophic factor (BDNF) and its cognate receptor, the tyrosine kinase B (TrkB), are normally expressed in neurons and implicated in multiple pathological conditions.
