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Finally, it is likely that Rac1 GTPase contributes to multiple pathological events and signaling pathways, which collectively facilitate neuronal damage and cognitive dysfunction following cerebral ischemia.
The triple transgenic mice harboring APPswe, tauP310L, and PS-1M146V (3xTg-AD) [36] have the advantage of the age-dependent development of multiple pathological events relating to AD.
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Our model-based CAD algorithm utilizes a Bayesian framework for determining the probability of multiple competing anatomical and pathological events throughout the lung.
Many evidences point out their involvement in a series of pathological events, such as arthritis, multiple sclerosis, cardiovascular diseases, inflammatory processes and tumor progression by degradation of the extracellular matrix.
The term delayed brain injury (DBI) describes critical events arising in the late phase of aSAH (3 14 days) resulting from the interaction of multiple pathological pathways as a direct consequence of EBI and leading to delayed cerebral ischemia (DCI) [ 93].
These data suggest that progression of liver fibrosis represents a complex process that involves several pathological events (HSC activation, inflammation etc); on this basis the inhibition of multiple pathological processes using a single drug might be uneffective.
Upon dysfunction of the BBB, multiple blood-borne elements other than albumin gain access to the normally-secluded brain environment, and can potentially initiate a sequence of pathological events.
Dysregulation of cell metabolism occurs under multiple pathological conditions.
Kreutzberg, G. W. Microglia: a sensor for pathological events in the CNS.
However, to date, no single disease model has serially linked these two pathological events using human neuronal cells.
This triggered perturbation generates cascades of pathological events that most likely alter the brain connectome.
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CEO of Professional Science Editing for Scientists @ prosciediting.com