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These observations, from model system C. elegans, make it tempting to speculate that the presence of Nef not only enhances the viral replication thereby increasing the viral load in host, but also contributes towards an increased pathogenesis leading to multiple pathological effects.
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IEMs have a myriad of pathological effects, affecting multiple organ systems that may lead to fatal phenotypes.
In conclusion, oleocanthal is a novel natural molecule possesses several beneficial effects via targeting multiple pathological aspects of AD, and holds a promise for development as a potentially effective AD drug.
At the pathological level, Smad7 targets multiple pathological processes required for oral mucositis development, particularly through its effects on proliferation, apoptosis, migration in keratinocytes, and reducing inflammation in the stroma.
Our studies show that the preventive and therapeutic effects of Smad7 are due to blocking multiple pathological processes of oral mucositis as discussed below.
In order to prevent the pathological effects caused by its dysfunction, regulation of AP-1 is complex and occurs at multiple interwoven transcriptional and post-transcriptional levels.
The pathological effects of electrical simulation on central nervous system tissue have been extensively investigated by researchers from multiple laboratories over many decades.
Dysregulation of cell metabolism occurs under multiple pathological conditions.
Thus, the eyelid contour change in TAO is caused by both mechanical and pathological effects.
Systemic immune indicators like eotaxin and fibroblast growth factor were evaluated for possible synergistic pathological effects.
Battelli, M. G., Polito, L., Bortolotti, M. & Bolognesi, A. Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects.
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