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Multiple pathological derangements contribute to the chronic hyperglycemia and hypertriglyceridemia that characterize type 2 diabetes mellitus (T2DM) [ 1– 3].
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Dysregulation of cell metabolism occurs under multiple pathological conditions.
Oral mucositis has multiple pathological processes, hence targeting one of them is insufficient for therapeutic efficacy.
Our study suggests that TGFβ contributes to multiple pathological processes responsible for oral mucositis development.
BRD4, a bromodomain and extraterminal domain (BET) family member, is an attractive target in multiple pathological settings, particularly cancer.
Elevated plasma insulin levels can lead to numerous metabolic and pathological derangements in various tissues, including the heart (27).
Multiple pathological pathways contribute to the final phenotype of PE.
The combination of physiological heterogeneity within microvascular networks, which is influenced by network architecture, and pathological derangements of blood movement caused by P. falciparum, may help to explain manifestations of cerebral malaria in retina and brain.
IL-1ra is capable of inhibiting IL-1 both in vitro and in vivo, thus representing a natural powerful mechanism to control IL-1-dependent responses and avoid pathological derangements (reviewed in [ 6- 8]).
In summary, it is postulated that multiple pathological reactions occur during ANFH.
They are also implicated in multiple pathological states, such as cancer, neurodegeneration and aging.
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