Sentence examples for multiple pathological changes from inspiring English sources

During the normal course of their life, these animals develop multiple pathological changes that are characteristic of premature aging [7].

Atrial fibrillation (AF) is the most common arrhythmia, especially among elderly populations, and is the end-stage manifestation of multiple pathological changes, including both structural and electrical remodelling.

Amongst multiple pathological changes in gene expression, AGE and ROS lead to the up-regulation of Ang-2 mRNA expression [ 28], which promotes vascular permeability, destabilization and sprouting [ 29].

Mono-target therapy often fails to treat chronic diseases that are often induced by multiple pathogenic factors and often involve multiple pathological changes, it is necessary to expand drug discovery toward multi-target approach.

As a means of addressing multiple pathological changes with a single therapeutically-relevant approach, we employed delayed transplantation of a unique class of astrocytes, GDAsBMP, that are generated in vitro by directed differentiation of glial precursors.

Delay in cataract development in Clock −/− mice compared with Bmal1 −/− mice can be explained by partial compensation of CLOCK function by NPAS2 or by the influence of multiple pathological changes in Bmal1 −/− mice.

These are the first data we are aware of examining the inter-relationship between pathological changes of multiple articular elements in a patient cohort.

RA is a complicated and treatment-refractory autoimmune disease, with complex pathogenesis and involving pathological changes in multiple targets [ 5, 27, 28].

This finding fits well with previous multiple sclerosis studies indicating early pathological changes in the thalamus such as atrophy, altered mean diffusivity, reduced N-acetyl-aspartate concentration and iron accumulation, whereas T2 lesions are more pronounced in the later stages of the multiple sclerosis disease (Minagar et al., 2013).

In spite of that, DTI alterations in multiple indices may help to elucidate early pathological changes in preclinical stages of AD.

These frameworks are heavily reliant on imaging endpoints, as multiple strands of evidence indicate that the pathological changes of AD gradually accrue over a period of many years before the onset of symptoms [ 62, 63].