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IL-17A-secreting CD4+ T cells (TH17) mediate resistance to mucosal colonization by multiple pathogens including S. pneumoniae.
G. mellonella waxworms are an in vivo infection model for multiple pathogens, including P. aeruginosa [ 25, 30, 36].
In this regarding, silencing of either SlSR1 or SlSR3L would relieve their suppression on PTI response and thus lead to increased resistance against multiple pathogens including B. cinerea and Pst DC3000.
While childhood diarrhea can be caused by multiple pathogens, including both bacteria and viruses, rotavirus is the most common cause of severe diarrhea leading to hospitalization or disease-specific death among children under 5 years of age [ 1, 2].
Hence, empirical antibiotic therapy must be supported by accurate knowledge of the epidemiology and resistance patterns when treating infections that may be caused by multiple pathogens including resistant microorganisms.
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Cryptocandin (from endophytic fungus Cryptosporiopsis quercina) [40] is an antimycotic drug against multiple human pathogens including C. albicans and Histoplasma capsulatum (causal agent of the lung disease Histoplasmosis), in addition to T. rubrum and T. mentagrophytes [41].
DCs cross-present fungal antigens to stimulate protective and damaging CD8 T cell responses to multiple fungal pathogens, including Pneumocystis species, Cryptococcus species, and Histoplasma capsulatum, among others [11], [32], [33].
The repeats-in-toxin (RTX) family of exoproteins is associated with the virulence of multiple human pathogens, including Escherichia coli, Bordetella pertussis, Serratia marcescens, and Pseudomonas aeruginosa.
NDM-1 provides bacteria with resistance to a large number of antibiotics; it is highly mobile and is found in multiple waterborne pathogens, including Vibrio cholera (Walsh et al. 2011) and E. coli (Kumarasamy et al. 2010).
Culex mosquitoes have emerged as important model organisms for mosquito biology, and are disease vectors for multiple mosquito-borne pathogens, including West Nile virus.
Evidence shows that autophagy is able to capture and degrade multiple categories of pathogens, including bacteria, viruses, and parasites [ 135].
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