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All of these disorders are associated with multiple pathogenic processes, so it is possible that effective treatment will require multiple complementary strategies.
The mechanisms of neuronal degeneration characterizing PD have been studied extensively and include a complex interplay among multiple pathogenic processes including oxidative stress, protein aggregation, excitotoxicity and impaired axonal transport [ 7].
Today it is commonly accepted that the clinical phenotype of the disease is the consequence of multiple pathogenic processes, involving motor neurons and surrounding non-neuronal cells, as well as myocytes 61.
It is commonly accepted that the disease is the consequence of a combination of multiple pathogenic processes, which take place not only in motor neurons but also in nonneuronal neighboring cells, such as astrocytes and microglial cells and, beyond the central nervous system, skeletal myocytes and, likely, other cells in the body [ 13– 17].
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While many of these protective effects were moderate, it is important to reemphasize that multiple interacting pathogenic processes contribute to stroke-induced neurodegeneration.
This is also in line with the idea that drugs such as desferrioxamine (mesylate) and posiphen that target multiple pathogenic molecules or processes in AD brain may hold the best promise in the clinical management of this complex and multifactorial neurological disorder [ 1- 5, 105, 108].
Crohn's disease (CD) and multiple sclerosis (MS) share common pathogenic processes.
Together, these studies demonstrate that multiple 14-3-3 14-3-3 14-3-3isoforms in pareogeninvolvedsses of PD, including apathogenicaberrant doprocessesofuction, and PDoteincludingg.
Of particular clinical relevance is that interfering with this seeding process could impact the aggregation of multiple pathogenic proteins and, hope-fully, impact the clinical progression of disease.
Anyone that argues that insights gained from animals are meaningless in understanding normal and pathogenic processes in the human body is either poorly informed or knowingly untruthful.
Considering the multiple pathogenic mechanisms, multi-mechanism-targeted therapy may have better effect than monotherapy.
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