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As a complex disease, CVD is the consequence of multiple pathogenic factors and reflects the altered interactions of many interconnected genes and gene products [9].
In general, it is accepted that the activity towards a single target is not sufficient for a complex disease involving multiple pathogenic factors (e.g., cancer, diabetes mellitus, neurodegenerative syndrome, cardiovascular diseases).
However, it seems certain that breaching of the protective barriers in the infected host represents a complex picture resulting from a combined activity of multiple pathogenic factors at different stages of disease.
Growing evidence highlights the importance of topical combination products targeting multiple pathogenic factors.
Similar to other inflammatory syndromes, GCA is a complex disorder with multiple pathogenic factors.
It is evident that any malignancy results from multiple pathogenic factors, and the related studies showed that any anticancer molecule was not universally effective to tumors [ 20].
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A recent study demonstrated that the number and function of EPCs decreased in the progression of sepsis and may be one of the main pathogenic factors in multiple organ dysfunction syndromes [ 5].
Just like other common psychiatric syndromes, BPD is known to have complex etiology including effect of multiple pathogenic genes and non-genetic factors [ 41].
Epidemiological studies have demonstrated multiple pathogenic influences associated with host, disease, and treatment-related factors.
These govern multiple functions, including hyphal development and the secretion of pathogenic factors.
Indeed, pathogenic factors can interfere at specific or multiple steps of one or more of the above described pathways by providing factors often structurally and/or functionally analogous to host regulatory proteins (Tato and Hunter, 2002).
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multiple pathogenic isolates
multiple pathogenic processes
multiple pathogenic events
multiple pathogenic influences
multiple pathogenic mechanisms
multiple pathogenic proteins
multiple pathogenic categories
multiple pathogenic pathways
multiple pathogenic mutations
multiple pathogenic targets
multiple pathogenic conditions
multiple pathogenic genes
multiple pathogenic bacteria
multiple pathogenic lineages
multiple pathogenic lifestyles
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