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In the present study, Fn14-TRAIL is introduced as a unique immunotherapeutic fusion protein that is designed to exchange and redirect intercellular signals within inflammatory cell networks, and, in so doing, to impact multiple pathogenic events and yield a net anti-inflammatory effect.
We will discuss the mechanisms by which genetic aberrations give rise to multiple pathogenic events required for myelomagenesis and conclude with a discussion of the clinical applications of these findings in MM patients.
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Considering the multiple pathogenic mechanisms, multi-mechanism-targeted therapy may have better effect than monotherapy.
Such culture systems are optimally suitable for the exploration of pathogenic events within a context of manageable complexity that can be subjected to multiple genetic, pharmacological, toxicological, or physical perturbations.
Asthma is a complex disease involving multiple pathogenic features including inflammation, mucus secretion, remodeling and bronchoconstriction.
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
No other pathogenic events in HR pathway genes were identified in these four HGSOC or corresponding PDX (Fig. 1b).
Involvement of several pathogenic events and their interconnections make this disease a complex disorder.
Moreover, as a complex disease, AKI does not have a single cause, but instead involves multiple pathogenic mechanisms13, such as renal tubular damage, inflammation, and fibrogenesis.
In Europe, Lyme disease is caused by multiple pathogenic species of Borrelia, said Per-Eric Lindgren, a professor of medical microbiology at Linkoping University in Sweden.
This technique is potentially useful for high throughput screening of multiple pathogenic bacteria in different samples.
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