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Microarrays offer the advantages of being capable to test a large number of samples simultaneously, screening for multiple pathogen types per sample and having comparable sensitivity to existing methods such as PCR.
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Our model accommodates these multiple pathogen and case detection methods.
The pool can be naturally occurring, as in the case of multiple pathogen strains in a blood sample, multiple types of cells in a cancerous tissue sample, or multiple isoforms of mRNA in a cell.
Immune protection against multiple pathogen epitopes may prevent pathogens from generating the multiple mutations required to escape immune recognition [ 7].
We next compared our dataset against a list of 511 common host response genes identified by Jenner et al., [ 18] in a meta-analysis of multiple microarray datasets investigating human host responses to multiple pathogens in different cell types.
Episodes could be associated with more than one type of pathogen if multiple pathogens were identified from the index specimen.
Arabidopsis RRS1-R, a chimera of a TIR-NB-LRR protein and a WRKY-type transcription factor, conferred resistance against multiple pathogens by the cooperation with the nuclear R protein RPS4 (Slootweg et al. 2010).
Traditionally, type 1 (polymicrobial) NF was the most common type of infection, emphasizing the synergetic effects of multiple pathogens [ 2, 3].
More general work on the use of the host system by pathogens [ 8] has found patterns in the types of interactions and infection strategies employed by multiple pathogens.
In natura, hosts are often infected by multiple pathogens.
Seven (35%) were colonized with multiple pathogens.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com