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This killifish is a particularly valuable non-traditional model, with multiple paralogs of AHR whose functions are not well characterized.
There are multiple paralogs of the RNA helicase present in microsporidian genomes, and again phylogenetic analysis reveals that the RNA helicase genes linked to the sex locus and the sex-related locus are also either paralogs or highly derived orthologs (Figure 5C).
Mammals have multiple paralogs of the core components.
Most organisms have multiple paralogs of USPs, where the number of copies depends on the organism.
Multiple paralogs of this family have arisen from repeated gene duplication events and are separately regulated in each organism.
Presence of multiple paralogs of CD33 gene may or may not result in increased 'CD33 pathway' activity.
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Phylogenetic analyses for these genes revealed the presence of multiple paralogs for the RAD51 family, the presence of two diatom homologs of SPO11 and the presence of a single RAD21 gene.
In the case of CHS, the presence of multiple paralogs in the genomes of most ascomycetes might facilitate rapid evolution leading to functional differentiation (Pacheco-Arjona and Ramirez-Prado 2014; Riquelme and Bartnicki-García 2008).
The presence of multiple paralog pairs of similar age is strong evidence of a large-scale duplication event (e.g., Wolfe and Shields 1997; Vision et al. 2000; McKain et al. 2012).
Extrapolated across the genome, the difference in the number of genes with multiple paralogs amounts to hundreds of new genes.
In contrast to Rht, the enzymes acting during the latter stages of GA biosynthesis are encoded by multiple paralogs with overlapping domains of expression and, in Arabidopsis, mutations in individual genes have more localised effects [ 20- 22].
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