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The excess of mutations in CpG sites might reflect subtle differences in the methylation pattern between the AVs and the reconstructed mutation group although problems with the parsimony reconstruction, such as excess of multiple parallel mutations in CpG codons in chimp and gorilla, cannot be ruled out.
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These mutations occur significantly more frequently together than alone in the complete Yg6 dataset, suggesting these mutations are shared by descent from a new source gene, rather than by multiple parallel mutation events.
Moreover, several control-region variants regarded as haplogroup diagnostic, such as C64T and A153G, show reversions: complete genome sequence data confirm the existence of multiple back and parallel mutations within haplogroup A2 [14], [14].
It is unlikely that the TT haplotype arose multiple times by parallel mutation, and there are two possibilities that could explain its prevalence among MSH22 ISX insertions.
We found that ten of the 23 different mutations were observed in multiple lines in this study, and seven of these ten parallel mutations were observed in multiple isolates in at least one line, suggesting that they had attained high frequency.
First, would the multiple, parallel evolutionary pathways converge to the same solution, or would we obtain different sets of mutations for a given substrate, depending on the pathway?
Large conferences may schedule multiple parallel sessions.
Why not try positive deviance or venture capitalist style multiple parallel experiments instead?
Dissemination from a solid tumor: examining the multiple parallel pathways.
Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways.
As a consequence, the dish contained multiple parallel inoculation strips.
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