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It is fairly common for intervention strategies aimed at changing multiple outcomes to have varying levels of success across outcomes.
As required by the funders, we aimed to examine the effects of YPDP on multiple outcomes to reflect the broad aims of the programme and pre-hypothesised measures before analysis (table 1).
This requires the correlation structure between effects on multiple outcomes to be appropriately modelled and also ensuring the mechanism of "borrow strength" across outcomes through the assumption of exchangeability of the random effect across outcomes.
We present here a robust and well-designed randomized comparative-effectiveness trial that also explores multiple outcomes to elucidate the potential mechanisms of mind-body effect for a major disabling disease with substantial health burdens and economic costs.
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This study has several strengths, including the prospective design and ability to measure multiple outcomes related to metabolic disruption by TCDD.
In contrast, Canonical Correlation Analysis (CCA) has the ability to analyze multiple outcomes at the same time.
Treatment with XR-NTX appeared to be feasible and was associated with a consistently large treatment effect across multiple outcomes relevant to the drug court setting.
DOI: http://dx.doi.org/10.7554/eLife.05913.004 Thus, self-organization based on synaptic adaptation can have multiple outcomes, leading to equivalently stable solutions.
In 1994 another SERM, raloxifene, was evaluated as an anti-osteoporotic agent in a clinical trial, the Multiple Outcomes Relevant to Evista (MORE) trial.
By using a cohort design, a specific population (rather than an isolated intervention or treatment) can be studied using multiple outcomes related to one or more exposures.
In either case, the emphasis needs to be laid on the measurement and identification of a concomitant influence of blood lead – alone or with other predictors – on multiple outcomes related to behavior.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com