Ortho Biotech Products, a unit of Johnson & Johnson, will pay Millennium $15 million up front and as much as $520 million later if Velcade wins approval in various countries for treating multiple myeloma and other types of cancers and if it achieves sales goals.
In the mutant genotype, cells containing multiple breaks or other types of chromosomal abnormalities occurred at much greater frequency.
Endogenous retroviruses, both HERV-W and HERV-H, were also reported in patients of multiple sclerosis and other types of autoimmune diseases [ 9, 10].
Characteristic site-specific degeneration patterns in patients with SCA6 could be useful for differential diagnoses, but comparisons with patients with multiple system atrophy, other types of SCA, or secondary ataxia are necessary.
But then, media companies typically trade at higher multiples than many other types of businesses, on the theory that they will grow faster.
Several highly potent bisphosphonates are now available for clinical use and represent an important adjunct in the management of bone metastases from breast cancer, multiple myeloma, and several other types of malignancies.
HPV16 was found in 45 (60%) tumors, HPV18 in 4 (5.3%), while multiple HPV infections and other types of HPV were found in 26 (34.7%) tumors (Table 3).
Comparable to the multiple comparison problem in other types of analyses, a conventional level of statistical significance of 5% would lead to the detection of SRB outliers as false positives in about five years over a period of 100 years, or in about three years over the 65 year period between 1946 and 2011 observed in our study (.05*65 = 3.25) [ 34].
Finally, we have included only patients with relapsing-remitting multiple sclerosis; therefore, our results cannot be extrapolated to other types of multiple sclerosis or to patients with more advanced disease (mean EDSS was 2.42).
Although we examined three common sources of multiplicity of data in trial reports, there are other types of multiple data in trial reports for example, different types of analysis such as intention to treat and per protocol analyses.
