Given their physical interaction with TORC1, all of these proteins, in addition to multiple other, as-yet-unconfirmed interactors, are potential substrates (or regulators) of TORC1.
When one considers that there are multiple converging pathways on ATF2, MK2 (and other substrates), as well positive and negative feedback loops that regulate activity and expression levels of enzymes and substrates, accurately predicting overall behavior becomes considerably more complex.
Although studied in less detail, similar substrate-induced trafficking controls have been reported for multiple other transporters in yeast.
Multiple steroidal hormones are capable of interacting with steroid transporters and competitively inhibiting metabolism of other substrates, in any tissue which contains these enzymes.
Although substrate induction observed in single substrate culture tended to repress the expression of other substrates' transporter genes (Additional file 1: Figure S1), the repression should be more stringent when multiple substrates are present.
The effective output state of the system was re-defined for the multiple step latches: for the two-step loops, the outputs were the sum of substrates P + P', and similarly for the other substrates Q, C, and D; for three-step loops, the sum of substrates P + P' + P".
Wooden doors open in one canvas, revealing other substrates beyond.
For the same substrate used in [10], only strong peaks corresponding to UV emissions were observed, whereas in the present work besides the strong UV emission peak, multiple other low intensity peaks appear.
No other substrates were identified yet.
