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In the future, it will be interesting to focus on the development of particular circuits and assess the temporal expression profiles of multiple other splicing regulators.
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Changes in lamin B1 levels induce through chromosome repositioning, modifications of the expression of multiple genes, including RAVER2, which is a modulator of PTB (20), and possibly other splicing regulators.
Similar to RBFOXi, PTBP1i did not interact with other splicing factors (Fig. 5a).
Collectively, this comparative analysis points to 13 SREs that might have some degree of specialization in splicing coordination or might participate in other unknown functions associated with the need for multiple intragenic splicing decisions.> On the other hand, there were four motifs for which no evidence for a splicing regulatory role was found in the literature.
In general, most genes give rise to multiple spliced transcripts by alternative splicing.
Klinck, R. et al. Multiple alternative splicing markers for ovarian cancer.
The variety of tropoelastin isoforms results from multiple alternative splicing of the primary transcript.
We identified multiple alternative splicing variants for each Cpeb.
In addition, most PDE genes encode for multiple splicing variants through the use of multiple promoters and alternative splicing.
Alternative splicing is critical for diversifying eukaryotic proteomes, but the rules governing and coordinating splicing events among multiple alternate splice sites within individual genes are not well understood.
In the event of multiple equally probable splice positions, the splice position with the shortest second piece is selected.
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