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Cord blood mercury was inversely correlated with the proportion of naive helper T cells and plasma IgM levels in cord blood but unrelated to multiple other measures of T-, B-, and natural killer cell proportions and function.

Moreover, while we cannot exclude the possibility that adverse effect burden is simply a proxy for medical and psychiatric morbidity, we note that independent effects of this variable persist after adjustment for multiple other measures of comorbidity.

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We compared the explanatory power of PC with those of multiple other clinical measures and biomarkers to determine the independent contribution that serial PC measurement would make in explaining mortality and DrotAA response.

These studies demonstrated statistically significant and clinically meaningful improvements compared with placebo in headache day frequency and multiple other headache symptom measures.

The third method used HAD scores as an anchor to relate to mean Catastrophising and Cognitive Coping scores as anxiety and depression have significant correlations with multiple other back pain measures [ 40– 40].

Early improvement in symptoms of schizophrenia in response to olanzapine LAI not only predicted later response in a total measure of symptoms of schizophrenia, but also predicted baseline-to-endpoint improvement across multiple symptom domains and other measures of quality of life, mental health, and social functioning.

Of note, we have discussed five important risk factors for CKD, but there are multiple other important factors and measures relevant to the prevention of CKD and its complications, such as acute kidney injury [ 94], alcohol use [ 95] and (dietary) interventions for obesity [ 7].

A similar finding was also observed in a phase II study of scyllo-inositol, although the finding (3.2 ml/year increase, P = 0.049) was not corrected for multiple comparisons and no other measures (whole brain, hippocampus and cortical thickness) showed any treatment effects [ 31].

Strengths of the study include assessment in a randomised and observational sample (with concordant findings); inclusion of a broad age range; and validation of the measure against multiple other health- and activity-relevant variables.

Only one study used objective physical activity measures; however, the multiple other shortcomings of this study limit the transferability of its findings.

Furthermore, quality of life is a multi-faceted phenomenon influenced by multiple other factors apart from those being measured in this study.

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