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"Over the past decade we've found that specific genes essential for the life of the bacterium, interact with multiple other genes in the cell in a complex web-like fashion, much like pages on the internet," Wright says.
Here, we develop a method by which existence or non-existence of such solutions can be demonstrated analytically in any given example of a general class of gene networks with steep sigmoidal interactions, under the assumption that any gene product that regulates multiple other genes does so at distinct thresholds.
That is, a strong mutation often has no apparent phenotypic effect only if multiple other genes remain functional.
For mRNA must be translated into protein to have a biological effect whereas microRNAs are themselves the active moiety, often influencing the expression of multiple other genes, and thus likely reflect altered physiology more directly.
While genetic ablation of mDia1 expression alone in mice resembles 5q- MDS, it is likely that mDia1 acts in concert with multiple other genes on the same commonly deleted region to suppress malignancy [8].
Notably, TIP60 was recently identified as one of the six 'hub' genes uncovered in a large-scale genetic interaction screen in C. elegans, so characterized by their ability to interact with multiple other genes and with all of the developmental signaling pathways screened in the study [24].
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Emerging studies also indicate that the heterogeneity of this disease probably also involves the contribution of multiple other gene products (Tomlinson et al, 2007; Wood et al, 2007) acting in various combinations to promote cancer development and progression.
Multiple other ADAMTS genes were later isolated and characterized by several groups [ 11– 211.
In addition to the HMGB1 TLR4 signaling cascade, multiple other proinflammatory genes are increased and have been detected postmortem in the brains of alcoholics.
We additionally showed that there are multiple other candidate genes for T2D and related QTs (fasting glucose, triglycerides, LDL, and HDL) that have diet-dependent roles in overall organismal viability.
Our observation of a similar phenotype in yeast with null mutations in multiple other autophagy genes, including ATG5, VPS30/ATG6, ATG7, and ATG8, provides additional support for the finding that the autophagy pathway is essential in cell cycle progression following nitrogen starvation.
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multiple different genes
multiple additional genes
multiple other people
multiple other communities
multiple other therapies
multiple other reports
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