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Further whole genome sequencing and comparative genomic analysis identified multiple orthologs of succinate semialdehyde dehydrogenase (gabD) that may compete with 4HB synthesis flux in H. bluephagenesis.
In mammalian cells, the situation is complicated by the presence of multiple orthologs of the archetypal PRC1 proteins.
Although it is widely appreciated that mammalian cells express multiple orthologs of the prototypic Pc, Psc, Ph and Sce proteins, the potential for combinatorial specificity has not been properly addressed [10], [43].
These data suggest that multiple orthologs of all Arabidopsis lignin proteins could be apparently found if enough number of Citrus ESTs were analyzed, indicating the relevance of the lignification process in Citrus.
In multicellular organisms, the autophagic machinery is more evolved and requires not only orthologs (or multiple orthologs) of yeast ATG genes but also genes whose homologs are absent in yeast but conserved in mammals.
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CEGMA analysis also identified multiple orthologs for 90%% of the identified CEGs.
Assigning functions via sequence similarity should be done with caution because genome duplication in species such as zebrafish has resulted in multiple orthologs for 15% of human genes (Howe et al. 2013).
In the case of multiple orthologs for a node, the orthologs are aligned independently of each other.
The extent of the occurrence of multiple orthologs varied among different complexes (Fig. 4B).
The method is taking advantage of complete genomes to find multiple orthologs and paralogs.
Again this was likely due to the higher a priori chance of a link being conserved when multiple orthologs existed and indeed this trend was also observed for all species pairs when comparing exclusively genes with multiple orthologs.
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