The authors concluded that the divergent ND2 haplotypes observed between lineages is consistent with multiple origins, followed by convergence on the eye loss phenotype [ 7].
Eukaryotic chromosomes possess multiple origins, each bound by the six-subunit origin recognition complex (ORC; composed of Orcs 1 6), which recruits the replicative helicase (the MCM complex) via interactions with Cdc6 and Cdt1 (Duncker et al., 2009; Bochman and Schwacha, 2009).
One difference to the CMAP database is necessitated by the multiple origins of the expression profile data represented by multiple probe ID definitions.
However, some studies found substantial genetic diversity, perhaps caused by multiple origins.
In eukaryotes, because chromosome replication is mediated by multiple origins, transcription-replication clashes often occur in a head-on mode, thus increasing the topological complexity.
Despite multiple origins of myofibroblasts as revealed by recent studies (LeBleu et al., 2013; Falke et al., 2015), the critical roles of macrophages in the formation and activation of myofibroblasts in renal fibrogenesis have been consensually appreciated (Vernon et al., 2010; Nikolic-Paterson et al., 2014).
Multiple origins for this group, either by HGT or duplication, would result in the distribution of these homologues all through the tree.
Myofibroblasts have multiple origins, possibly appearing, for example, by differentiation of local, resident fibroblasts in response to proteins or by the migration of microvascular pericytes into the lesional area [ 1].
As an example from a later stage of evolution, pointed out by Maynard Smith and Szathmáry (1997): There seem to be many ways in which multicellularity can arise, as evidenced by its multiple origins on Earth, but the origin of eukaryotes may have happened only once and may have required a very specific set of circumstances to have produced the functional characteristics we observe today.
However, other accessions of S. verticillata are placed elsewhere, and the authors suggest that this is caused either by the multiple origins of the polyploid and/or homoplasy in the distinguishing characteristic of the retrorse barbs on the sterile bristles in the inflorescence.
