TTP results from excessive platelet aggregation in multiple organs with, consequently, a dramatical increase in shear stress caused by the accumulation of unfolded high-molecular weight von Willebrand factor multimers in plasma.
Our results indicated that the RASSF9 mRNA was expressed in multiple organs, with high-level expression seen in the skin, moderate-to-high expression in the heart, lung and kidney, and relatively low expression in the thymus, brain, stomach, liver, intestine and spleen (Figure 11A).
Systemic lupus erythematosus (SLE) is a syndrome affecting multiple organs with circulating autoantibodies of complex specificities.
Miliary TB is a form of TB where there is haematological dissemination from focal infection into the blood, leading to seeding of multiple organs with TB bacilli.
When transferred to humans from an unidentified animal reservoir, Ebola virus replicates rapidly in macrophages and dendritic cells, causing intense inflammation, high viremia, and spread of infection to multiple organs, with fever, coagulation abnormalities, and shock (10 ).
In animal experiments, airborne PM2.5 have been shown to increase levels of LPO and alter intracellular redox status in multiple organs with decreased SOD, catalase, and GSH-Px activities and depleted GSH levels (Liu and Meng 2005).
One colon cancer patient with metastases in multiple organs treated with Her2 third-generation CAR T cells died, which led to discontinuation of that trial [ 114].
A few mice had cellular infiltrates in multiple organs consistent with bacterial infection.
The patient developed septic shock with multiple organ failure, with identification of MRSA from multiple sites.
Indeed, autoimmune diseases have been found to develop in multiple organs in humans with AID mutation [5].
These results suggest that PMX-DHP could save more lives in patients with septic multiple organ failure with IL-6>IL-6> pg/ml when applied early after the onset of shock.
