However, T2DM is a kind of disease involving defects of multiple organs, which cannot be distinguished through the measurement of the serum-glucose level.
The complex nature of SLE with fluctuating levels of disease activity involving one or multiple organs, which may vary between patients and within the same patient over time, continues to challenge SLE investigators.
Severe sepsis and septic shock may induce ischemia or hypoxia in multiple organs, which further increases the change in xanthine/hypoxanthine to UA through activation of xanthine oxidase in microvascular endothelium [ 30, 31].
In advanced disease, fibrosis of the skin and of multiple internal organs, which results from excessive extracellular matrix production of activated fibroblasts, is the most obvious histopathological hallmark of SSc.
Most IMs are connective tissue diseases that can affect multiple organs, among which the most common targets are the skin, joints, and lungs.
Restoration of function is directed at multiple organ systems, which support visual acuity, airway patency, mastication, lacrimation, smelling, tasting, hearing, and facial expression.
The mortality can reach as high as 85% in the presence of a hyperadrenergic crisis [3 5], a life-threatening endocrine emergency leading to multiple organ failure, which is characterized by hypertensive crises, subsequent cardiogenic shock, pulmonary edema, acute liver and renal insufficiency, encephalopathy, and hyperthermia [2, 6].
Some patients died with derangements in multiple organ systems, which led to their demise.
This is not surprising in the context of multiple organ failure, which may be caused by systemic microcirculatory failure.
Sepsis aggravated ongoing brain dysfunction as a component of multiple organ dysfunctions which was reflected by S100B elevation and higher organ dysfunction SOFA scores, respectively.
POD builds on our understanding of multiple organ dysfunction, which is central to the pathogenesis of death and disability in critically ill patients.
