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This fibrotic response shares common features in multiple organs that can be affected by these disorders.
Examples presented in this review highlight the potential of a chemical to affect development in multiple organs that use the same fundamental patterning and developmental building blocks.
Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease affecting multiple organs that is characterized by circulating antibodies to nuclear antigens.
Elevated levels of ET-1 have been observed in multiple organs that are affected by SSc, notably blood vessels, lung, kidney and skin [ 24].
IgE-binding can occur in the oral cavity causing localized allergic reactions that are typically mild, or they can occur after uptake by the gastrointestinal tract, causing systemic allergic reactions involving multiple organs that can be more severe.
Inclusion criteria for this substudy are: patients without family history of breast or ovarian cancer but with at least one of the following risk factors for hereditary predisposition; early onset breast cancer defined as diagnosis at or younger than age 40, bilateral breast cancer, personal history of breast and ovarian cancer, male breast cancer, or cancer of multiple organs that include breast.
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Hormones stimulate metabolic changes in multiple organs so that nutrients and energy can be diverted to the fetus to support growth during pregnancy and then to the mammary gland to support milk synthesis at the initiation of lactation [17] [19].
The promising results in multiple organs suggest that further insight into regenerative mechanisms and novel clinically relevant therapeutic approaches will emerge from zebrafish research in the future.
This finding and the observation that the transcript levels of TaPMM-D2 were considerably lower than those of TaPMM-A1, B1 and D1 in multiple organs indicate that TaPMM-A1, B1 and D1 are likely to be the main active PMM isozymes in bread wheat tissues.
Within an individual patient, for example, there are multiple organ systems that follow physiological rules governing their interactions that aggregate up to the health of that individual.
Imai and colleagues [ 7] indicated that remote cellular damage also occurs and that this may contribute to the multiple organ dysfunction that often accompanies ARDS.
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