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Patients with multiple organs involved are more likely to have triple-negative disease [ 16– 16].
Exercise induced autophagy in multiple organs involved in metabolic regulation, such as muscle, liver, pancreas and adipose tissue.
It has been shown that exercise induces autophagy in multiple organs involved in metabolic regulation including muscle, liver, pancreas, and adipose tissue [ 230].
In the multiple organs involved in diabetes and obesity, cells experience stress with nutrient excesses, leading to organelle dysfunction, including mitochondrial stress [ 10], peroxisomal oxidative stress [ 11, 12], and endoplasmic reticulum (ER) stress [ 2], which are thought to be pathological factors in diabetic nephropathy [ 11– 11].
Improved response rates in patients with multiple organs involved have, however, been reported previously; a study of docetaxel in patients with advanced breast cancer reported the highest response rate in those with more than two organs involved (83.3%%, compared with 62.5 % in those with one organ involved and 45.5 % in those with two organs involved) [ 15].
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Because shear stress is greatest in the brain and kidney, these organs are most involved, although multiple organs are involved as well [ 9- 16].
Multiple organs were involved in 11 patients.
Although multiple organs are involved in glucose homeostasis, the liver is the major player.
In addition, the evaluation of the compound effects in vivo is especially important when multiple cell types and possibly multiple organs are involved in the toxicologic response.
Patients with severe complications had a mean 10-day CPIS value of 5.3, 7.1, 8.1 and 8.4 for patients with single organ failure (survival rate 100%), for patients with pulmonary contusion (survival rate 65%), for patients with severe sepsis (survival rate 26%) and for patients with multiple organ failure syndrome (>2 organs involved, survival rate 17%), respectively.
Systemic erythematosus lupus (SLE) affects multiple organs and involves complex immune dysfunction.
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