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This study is the first to describe the in vivo global transcriptional response of multiple organs during inhalational anthrax.
10 The Hh signaling pathway is crucial for the growth, patterning and morphogenesis of multiple organs during embryonic development.
Histopathological changes occur in multiple organs during the acute infection, but are not restricted to the organs where sequestration takes place.
There, we found an unusually fulminant progression from a single small osteolytic lesion to widely disseminated metastases in multiple organs during hormonal treatment for oocyte harvest before the planned chemotherapy.
The present review summarizes the temporal and spatial distribution of PEDF in multiple organs during developmental stages and adulthood, and discusses its implication in diabetic and hypoxia-induced angiogenic diseases.
Histological changes and host cell damage, observed in multiple organs during a primary blood-stage infection, are similar to those observed in P. falciparum and P. vivax malaria in humans.
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Autophagy is implicated in homeostasis and cell-size regulation in multiple organs both during normal development and under stress conditions.
PITX1 and PITX2 have been shown to be either co-regulated or functionally overlapped in multiple organs including hindlimb during embryonic development (St Amand et al., 2000; Marcil et al., 2003; Lamba et al., 2008; Castinetti et al., 2011).
These models provide the opportunity to manipulate disease processes and look at multiple organs in depth during the early disease state as well as disease progression, which is particularly difficult to achieve in humans but is essential in developing new therapeutic strategies.
The exquisite cell-type-specific expression of the Fgfr2-IIIb and Fgfr2-IIIc isoforms underlies reciprocal communication between epithelium and neighboring mesenchyme, wherein the ability of the epithelial Fgfr2-IIIb receptor to respond to mesenchymally expressed Fgfs, and vice versa, has proven essential for the development of multiple organs and appendages during embryogenesis.
Secondary outcomes: Free days of MV, RRT and vasopressor support during the first 28 days after randomization; Multiple organ dysfunction during the first 72 h after randomization [26]; Intensive care unit (ICU) and hospital lengths of stay; All-cause mortality at 90-day.
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