There were two parameters used for selection of the best modality for multiple organ procurement/transplantation, ie, average number of organs procured from an individual donor and the success rate for multiple organ procurement.
This study was also conducted in accordance with French law concerning multiple organ procurement.
A1 was the best modality for multiple organ procurement, but was not significantly better than A2 and A4.
We selected the best hormonal replacement modality for successful multiple organ procurement using a two-step approach.
To select the optimal modality for single and multiple organ procurement, multiple comparison procedures (MCA, MCC, and MCB) were applied based on the logits from either the logistic regressions or generalized linear mixed models (GLMM).
The detailed hormonal replacement combinations for each organ type and multiple organ procurement are summarized in Table 4. Hormonal replacement therapy has been widely used to increase organ procurement from human brain-dead donors.
Although there was some variation in the optimal combination of hormones for a specific organ, the combination of thyroid hormone, a corticosteroid, antidiuretic hormone, and insulin was the optimal hormonal therapy to maximize multiple organ procurement.
The simultaneous confidence intervals on the parameters of interest for the multiple comparison procedures were constructed to assess efficacy for each hormonal modality for individual and multiple organ procurement.
Based on the available UNOS data, and using the proposed best treatment selection method, we cautiously recommend that the combination of all four hormones is the optimal modality for multiple organ procurement for transplantation.
1– 7 Although there are reports demonstrating that combination hormonal therapy can significantly increase the number of organs that can be procured from each brain-dead potential donor, the optimal regimen that maximizes multiple organ procurement and improves organ quality remains uncertain.
