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Hayes KC, Potter PJ, Hsieh JT, Katz MA, Blight AR, Cohen R. Pharmacokinetics and safety of multiple oral doses of sustained-release 4-aminopyridine (Fampridine-SR) in subjects with chronic, incomplete spinal cord injury.
Multiple oral doses of genistein significantly protected mice against γ-irradiation [ 31, 32].
The multiple oral doses of larazotide acetate used in this study were well tolerated.
(Table 3) On DL 1, pre-treatment with multiple oral doses of 200 mg b.i.d.
Significant tivantinib accumulation in plasma was observed after multiple oral doses.
This allowed us to evaluate the effect of multiple oral doses of sorafenib on the pharmacokinetics of cyclophosphamide.
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Multiple oral dosing of MK-8931 lowered Aβ levels in the CSF by over 90%.
The initial elimination half-life in normal dogs has been reported to range from 37−73h after multiple oral dosing [ 96].
5-FU pharmacokinetics during multiple oral dosing of eniluracil and 5-FU have been reported by Baker et al (2000).
Overall, mean PK parameters of apatinib after single and multiple oral dose administration are summarized in Table 2.
CF101, in single and multiple oral dose studies, was found to be safe and well tolerated, and the pharmacokinetics were linearly proportional to dose [ 14].
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