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Recently a dog with multiple oral SCCs that contained a novel papillomavirus (PV) was reported.
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However, around 15% of oral SCCs cannot be explained by these risk factors.
Oral SCCs are frequently accompanied by such precancerous lesions which spread out around them.
While it appears CPV-17 is only rarely present in canine oral SCCs, evidence suggests that this PV could influence the development of oral SCCs in this species.
Particularly in oropharyngeal SCCs, overexpression of p16 notably demonstrates a strong correlation with HPV infection, although it has failed to reveal such strong correlation with oral SCCs [15].
In addition, chronic inflammation, including periodontitis, has been regarded as a possible risk factor for oral SCCs.
Risk factors for oral SCCs are smoking, tobacco and betel quid chewing habits, and heavy alcohol consumption.
Human oral SCCs, normal oral mucosa and normal skin were obtained with appropriate ethical approval.
Abnormal transcripts of the FHIT gene were found in eight of 15 oral SCCs.
There is compelling evidence that immune responses are impaired in patients with oral SCCs.
The copy numbers of chromosomes 7, 9, and 11 were analyzed in 77 primary oral SCCs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com