However, both nesprin-1 and nesprin-2 show extensive alternate splicing, and variants have been shown to localise to multiple nuclear and cytoplasmic compartments.
We studied the localization of a nuclear lipid, phosphatidylinositol-4,5-bisphosphate (PIP2) in the nuclear compartments by means of multiple immunolabeling using our system of novel nanoparticles.
Multiple neutrophil autoantigens both from the cytosolic, granule and nuclear compartments are targeted by such autoantibodies, which for clinical clarity's sake should be termed 'neutrophil-specific autoantibodies' (NSAs) and not ANCAs [ 22].
An appreciation of this difference rationalizes the need for multiple endonucleases that target different junctions in varying cellular contexts (replication, recombination, meiosis) and possibly in different nuclear compartments.
It is based on two spatially co-aligned, active and inactive nuclear compartments (ANC and INC).
Genes can be localized to specific nuclear compartments in a manner reflecting their activity.
Response of nuclear compartments to clastogen insult in terms of chromosomal aberrations is not uniform.
Of note, genome replication and capsid assembling events occur in different nuclear compartments [16].
Phospho-PTEN was present in both cytoplasmic and nuclear compartments.
Furthermore, transcriptionally repressed or active areas occupy different nuclear compartments.
