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As a result, multiple neutral mutations in the form of publishers (or subscribers) tuned to the same signal can accumulate as neutral changes with no effect on fitness.
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This approach, however, has not been extended to the analysis of multiple linked neutral mutations.
This can be explained by the accumulation of multiple neutral and/or intragenic compensatory mutations.
Indeed, multiple neutral changes along the mutational landscape of a protein may precede mutations with high advantageous fitness effect [ 27].
Thus, SPALSH is able to overcome some of the limitations of linear multiple-sequence aligners, and specifically it does not discard sites due to varying module grammar, or neutral mutations.
Simply, population size does not effect on neutral mutations.
J.F. Crow, "The dilemma of nearly neutral mutations.
She (Tomoko Ohta) independently invented the near neutral theory which is mostly focusing on nearly neutral mutations as opposed to neutral mutations.
Different mutations exist such as gain or loss of function mutations and neutral mutations.
The main difference between Ohta's nearly neutral theory and Kimura's neutral theory is while Kimura put his focus on so-called "strictly neutral mutations" (this phrase is specified by Ohta), Ohta was more interested in the evolutionary mechanisms of the "border line mutations" or the "nearly neutral mutations," (i.e. mutations which are not strictly neutral nor are strongly selected).
But most mutations are neutral in their effect.Sexual reproduction mixes up the DNA, distributing neutral mutations around the population.
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