It has also become apparent that schizophrenia shares risk alleles with other neuropsychiatric phenotypes, such as bipolar disorder, major depressive disorder, autism spectrum disorder, intellectual disability and attention-deficit hyperactivity disorder.
Due to its role in clearing serotonin from the synaptic cleft, SERT plays a central role in neurotransmission and a broad role in brain activity making it a sought after therapeutic target of multiple neuropsychiatric disorders [170].
Furthermore, some of these CNVs were found to be associated with a broad range of neuropsychiatric phenotypes crossing the traditional boundaries of diagnosis [9].
Recurrent deletions of chromosome 15q13.3 are associated with developmental delay and a variety of neuropsychiatric phenotypes.
The prefrontal cortex was chosen given its diverse functions relative to human cognition and of importance to neuropsychiatric phenotypes.
Using this method, the clustering of the metabolic, immune, neoplastic, and neuropsychiatric phenotypes are considered significant (p ≤ 0.05).
Small duplications and deletions on 15q13.3 have been found to be associated with neuropsychiatric phenotypes that include ADHD.
Spontaneous locomotor activity in a new environment can provide information on neuropsychiatric phenotypes in mice associated with genetic mutations.
There are limited published data on the use of array CGH in adults with unexplained complex neuropsychiatric phenotypes.
36 Zhang et al observed the association of gene variants of the BDNF gene and several neuropsychiatric phenotypes.
