The consortium brings together seven major industry partners who are willing to collaborate to develop significant advances in major neurological disorders such as Alzheimer's, Parkinson's, multiple sclerosis, and neuropathic pain.
A substantial subset of patients with SFN is aged 65 years or older, and these patients often exhibit comorbidities and usage of multiple drugs, making neuropathic pain treatment more challenging.
The CX3CL1-CX3CR1 axis has been implicated in multiple pathologies, including atherosclerosis, multiple sclerosis, rheumatic diseases, and neuropathic pain.
S1Rs are involved in a large range of basic biological processes and multiple chronic disease states, including neuropathic pain, depression, Alzheimer's disease (AD), and schizophrenia [2 5].
A total of 302 consecutive patients with multiple sclerosis were screened for neuropathic pain by clinical examination and the DN4 tool.
Ibudilast has also recently shown promise as a treatment for neuropathic pain, in multiple rat models, via its ability to attenuate glial cell activation [30].
Cardinal features of neuropathic pain in multiple sclerosis include hypersensitivity to cutaneous mechanical and thermal stimuli in the distal extremities [ 10, 12- 14].
For example, in a mouse model of multiple sclerosis, only females exhibit neuropathic pain (sensitivity to mechanical, cold, and heat stimulation), even when motor dysfunction does not differ between the sexes [ 141].
In this clinical and neurophysiological study, we examined the clinical characteristics and underlying mechanisms of neuropathic pain related to multiple sclerosis.
However, it can be useful in other peripheral neuropathies such as chemotherapy-induced peripheral neuropathy, diabetic neuropathy, osteoarthritis, failed back surgery syndrome, dental pain, neuropathic pain in strokes, multiple sclerosis, chronic pelvic pain, post-herpetic neuralgia and vaginal pain [10].
