In hippocampus or cortex many finely branching processes from a single astrocyte are estimated to contact several hundred dendrites from multiple neurons and to envelope 100,000 or more synapses [ 34, 91, 172].
As with wildtype animals, combining information from multiple neurons tended to increase the accuracy in these mutants and tph-1 expression in the NSM and ADF neurons accounted for the majority of this representational capability.
With a single electrode, we simultaneously recorded extracellular action potentials from a single neuron and those from background multiple neurons at the same sites or recorded multineuronal responses at successive sites along electrode penetrations, while monkeys performed a fixation task.
Together, these results show that a combinatorial code of activity across multiple neurons is essential to drive plasticity in an animal's behavior to BZ odor.
Using networks of rat neocortical neurons and glia grown over multi-electrode arrays (MEA), we observed the timing of direct electrically-evoked action potentials (dAPs) in multiple neurons changed up to 4 milliseconds (40%) after minutes of recording and up to 13 milliseconds (74%) after hours, adapting to different patterns of low frequency stimulation.
It is therefore important to understand how the responses from multiple neurons can be combined to increase the reliability of coding of attention and how the noise correlations influence the combined reliability.
We used a multi-electrode array to induce, detect, and track changes in propagation in multiple neurons while they adapted to different patterned stimuli in controlled neocortical networks in vitro.
Since for each penetration we recorded multiple neurons, restricting our analysis to pairs of neurons may have overlooked interactions involving more than two neurons.
Note that in this context synchrony does not refer to the degree to which multiple neurons fire action potentials simultaneously at millisecond time precision.
The investigation of distributed coding across multiple neurons in the cortex remains to this date a challenge.
