At the level of the spinal cord, there are multiple secondary neurons that receive the stimulus-induced input.
One possibility is induction of multiple MyHC isoforms following denervation and reinnervation by multiple motor neurons that specify distinct myofiber types (Pette and Staron, 2000).
Overall, parylene-C and SiO2 coated with Fn hosted the richest neuronal populations, with neurons that extended multiple long processes (white arrows in Fig. 4A and D).
Recordings from 61 superficial layer cells revealed 19 neurons that produced multiple action potentials following stimulation.
It is also important to note that there are a number of examples in the literature of neurons that have multiple action potential initiation sites, which can serve different functions, as reported here.
DOI: http://dx.doi.org/10.7554/eLife.06683.014 npr-17 was shown to be expressed in ASI neurons (Harris et al., 2010), a pair of head sensory neurons that regulate multiple food-related effects such as quiescence, dauer formation, and caloric-restriction-induced life span increase (Inoue and Thomas, 2000; Bishop and Guarente, 2007; Gallagher et al., 2013b).
Synapse formation and maturation require multiple interactions between presynaptic and postsynaptic neurons that are mediated by a diverse set of synaptic proteins (Han and Kim, 2008; McMahon and Diaz, 2011; Siddiqui and Craig, 2011).
The hem expresses both Zic2 and Ngn2, which accounts for their overlap in Figure 3 F. Cajal Retzius cells are early-born neurons that arise from multiple origins and are thought to control radial migration of cortical neurons via the reelin-Dab1 signaling pathway (Howell et al. 1999; Tissir and Goffinet 2003).
They also found that light modulated the activity of a subset of trigeminovascular thalamic neurons that receive input from the retina and project to multiple cortical areas [62].
On the latter account, multiple cortical regions contain neurons that exhibit properties (e.g., oscillations at different rates, ramping behaviour) that would be appropriate for measuring time intervals; these neurons are assumed to project to the medium spiny neurons of the striatum where they are integrated to detect patterns of input that correspond to a specific time interval (see [32]).
