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However, to find multiple network alignments, IsoRank uses these scores in a time-intensive greedy algorithm.
Nevertheless, the Graemlin algorithm was the first algorithm capable of performing scalable, multiple network alignments [ 39].
Additionally, it may be possible to modify the star spread to account for existent gold standard network homology data, yielding even higher fidelity multiple network alignments.
The newer version, Graemlin 2.0 [ 40], is a global alignment algorithm that can adjust scoring function parameters and perform multiple network alignments.
With the novel representation of a layered alignment graph, NetworkBLAST-M can achieve dramatic reductions in run time and memory requirements for multiple network alignments.
Performance evaluation based on synthetic networks as well as real protein-protein interaction networks shows that the proposed algorithm can construct more accurate multiple network alignments compared to other leading methods.
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For multiple network alignment experiments, PINALOG was excluded as the algorithm can only handle pairwise alignments.
Further directions for research include extending this approach to multiple network alignment and to network querying.
In recent years, several multiple network alignment methods have been developed.
A multiple network alignment algorithm must thus efficiently identify a biologically appropriate mapping between the genes.
Recently, a number of multiple network alignment algorithms have been proposed [ 12- 14].
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multiple network devices
multiple network nodes
multiple network interfaces
multiple network analyses
multiple network operators
multiple network attributes
multiple network motifs
multiple network realisations
multiple sequence alignments
multiple network configurations
multiple network models
multiple network intrusions
multiple network architectures
multiple network topologies
multiple network stages
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