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The CNC syndrome is a genetically heterogeneous disease associated with multiple neoplasms, such as skin, cardiac, and breast myxomas, as well as endocrine tumours.
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Such an entity of multiple neoplasms is not rare or new, being described by Billroth as far back as 1889. 1 In 1932, Warren and Gates published the first study of 1,259 patients with multiple neoplasms.
This is due to marrow infiltration and, although commonly described for osseous lymphoma, it is also found in other small round cell neoplasms such as Ewing sarcoma and multiple myeloma.
Such improvement has caused a surge in the number of surviving patients with secondary multiple neoplasms, posing an additional threat in terms of morbidity and mortality.
Bone forming neoplasms such as osteosarcoma.
This includes neoplasms such as metastases, lymphoma, leukemia or sarcoma.
The radiological features do not help to distinguish them from malignant neoplasms, such as rabdomyosarcomas (Fig. 13).
Calcification can also form in neoplasms such as chondrosarcoma or osteosarcoma as a natural process of the disease [2].
The differential diagnosis includes splenic haemangioma and other primary splenic neoplasms such as lymphoma or splenic angiosarcoma [30].
Location of the principal neoplasm was defined as that of the most advanced lesion in a patient with multiple neoplasms.
Between January 2005 and December 2012, of 1,873 consecutive cancer patients, 1,551 (82.8%) had a single primary neoplasm and 322 (17.2%) had multiple neoplasms.
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