Sentence examples for multiple negative regulators from inspiring English sources

The existence of multiple negative regulators ensuring a tight regulation of the NF-κB pathway, however, raises the question of the specific role of each of these regulators and the relationship between them.

Additionally, chondrocytes suppress, in a contact-dependent manner, the proliferation of activated T cells, with suppression associated with chondrocyte expression of multiple negative regulators of immune responses, including B7 family members (B7-H1, B7-DC, B7-H3, B7-H4, and B7-H4), chondromodulin-I and indoleamine 2,3-dioxygenase.

Importantly, multiple negative regulators of signal transduction, secondary metabolite biosynthesis and cell differentiation were revealed.

The ability of ActRIIB-Fc to inhibit the multiple negative regulators is a feature that presumably would result in a broader inhibition of the negative regulators and provide a more maximal effect on UCP1 up-regulation compared with targeting the ligands individually.

Multiple targets of miR-510 are predicted to directly target multiple negative regulators and effectors of the Akt signaling pathway and, therefore, a potential mechanism of miR-510-mediated increase in cell proliferation, migration, invasion and tumor growth could be through hyperactivation of the Akt signaling pathway.

Multiple positive and negative regulators have critical roles in the regulation of the TGF-β/Smad signaling pathway.

These findings indicate that the PcG/TrxG targets are regulated by multiple positive and negative regulators that facilitate the establishment and removal of PcG repression.

Taken together, our data indicate that CENP-A affects HCC cell proliferation via the coordination of multiple positive and negative regulators of cell-cycle progression.

This is achieved through the concerted action of multiple positive and negative regulators acting basally and during inducible signaling.

Bioinformatic analysis suggests that the middle segment of MAVS forms random coils, which, if present by themselves in aqueous phase, would not likely be fully extended and thus may deter efficient binding of multiple positive or negative regulators of MAVS.

Thus, the expression profiles of this set of proteins imply an increase in ET production in senescing leaves. ET signal transduction supposedly follows a "linear" pathway, with membrane-bound receptors at the beginning, multiple positive and negative regulators in between, and TFs at the end of the chain.