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Despite its success, this approach again requires multiple nasal administrations to maintain efficacy against EAE.
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Histopathological study of the nasal mucosa suggested that the formulation was safe for nasal administration.
OVA TMC showed little toxicity to the nasal epithelia or cilia of rats after nasal administration for three consecutive days.
Fig. 1 Histopathological observation of lungs of mice after nasal administration of TiO2 NPs for 6 months (n = 5).
Fig. 3 Histopathological observation of hearts after nasal administration of TiO2 NPs for 6 months (n = 5).
Nasal administration of murine Lptn with protein antigens promoted both mucosal and systemic immunity (Lillard et al., 1999b).
The cytoxicity and the change of the blood glucose concentration after nasal administration of this hydrogel were also investigated.
The horizontal Ussing chamber method was a suitable tool for the evaluation of gels for nasal administration.
Modified PLGA microspheres (cationic microspheres) thus produced humoral (both systemic and mucosal) and cellular immune responses upon nasal administration.
Here we designed a highly tunable polymeric hybrid micelle (PHM) system offering good vaccine efficacy after nasal administration.
The nasal administration of genetic human IL-2 enhanced antigen specific cellular immune response, which provided long lasting protection from disease progression (Bertley et al., 2004).
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