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The use of thalidomide has been shown to improve response rates in patients with multiple myeloma; however, no increase in overall survival has been observed.
The patients with multiple myeloma however, had higher median serum creatinines at presentation.
In patients with multiple myeloma, however, the clonal proliferation of plasma cells can produce FLCs in quantities thousands of times higher than normal [ 3].
Curcumin anti-tumor effects were previously characterized in multiple myeloma, however only few MM cell lines were included in these studies.
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Autologous transplantation improves survival in multiple myeloma patients, however, most eventually relapse.
However, multiple myeloma is still an incurable disease, and patients will eventually relapse after front-line therapy.
However, despite these advances, multiple myeloma is still thought to be an incurable disease.
(20) However, whether GA has an ability to suppress HIF-1α/VEGF expression via inhibition of PI3K/Akt/mTOR signaling pathway under hypoxia in human multiple myeloma cells still remains unclear.
Aim: PET/CT is increasingly used to evaluate multiple myeloma (MM) bone lesions, however, 18F-fluorodeoxyglucose (FDG), the reference radiopharmaceutical in oncology, shows in this indication relatively low sensitivity.
The importance of telomerase in multiple myeloma (MM) is well established; however, its response to bortezomib has not been addressed.
However, many multiple myeloma patients frequently had no response to these agents and their prolonged exposure induced toxicity even in normal cells.
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