Treatment with 10e also showed a decrease of Itch level in human RPMI-8226 myelomae myeloma cells.
Furthermore, the IGF-1R inhibitor even managed to knock down multiple myeloma cells resistant to standard treatments.
Compound 38 (IC50 = 26.7 μM) is slightly more potent than 9 (IC50 = 34.3 μM) at inhibiting survival of dexamethasone-resistant (MM.1R) human multiple myeloma cells.
We used tunicamycin induction of the unfolded protein stress response in multiple myeloma cells to generate a mass response that was temporally profiled for hundreds of cells simultaneously.
(B) The immunoreactivity of 125I-labeled B-B4 mAb was estimated by measuring the binding of a constant concentration of 125I-labeled B-B4 mAb to increasing numbers of U266 multiple myeloma cells that strongly expressed the CD138 antigen.
These include small cell lung cancer cells and multiple myeloma cells [18], [33].
Huang et al. have reported that ATRA intensifies rosiglitazone-induced growth inhibition and differentiation in multiple myeloma cells [34].
SHP1 mediates the inhibition of Stat3 signaling induced by either butein or boswellic acid in multiple myeloma cells [29], [30].
We have previously reported that edelfosine induced co-aggregates of rafts and Fas/CD95 in leukemia Jurkat T-cells and multiple myeloma cells [1], [4], [7].
A surface antigen overexpressed on multiple myeloma cells known at HM1.24 was subsequently shown to be identical to BST-2 [17].
This idea is further supported by the exquisite in vitro sensitivity of multiple myeloma cells, which express high levels of constitutively activated Stat3, to avicins [19].
